Folate deficiency represents one of the most common nutritional deficiencies and may occur when dietary intake is inadequate, when an increased need is not matched by an increased intake (particular physiological conditions such as pregnancy, lactation, child growth), when there is altered absorption/excretion (or losses) and when metabolism or drug use interferes with the ability of the body to use folate. Several conditions can lead to nutritional folate deficiency such as enzyme defects, malabsorption, digestive system pathology, liver disease but also conditions with a high rate of cell turnover such as rapid tissue growth (infants, kids and adolescents) pregnancy and lactation. In severe cases, deficiency can cause many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth neural tube defects (NTDs) and carcinogenesis. Folate deficiency is associated with elevated levels of homocysteine, cerebrovascular and neurological diseases, and mood disorders.
Good food sources:
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