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This Is Your Brain on Change
Women's Health US
|Spring 2025
Big moves and major decisions impact you on a molecular level. Here's how to harness it all for smooth sailing.
Two major life changes hit me at the same time, roughly seven years ago: moving to a big city and going to college. I couldn't wait to finally begin the adventure. But by the time August rolled around and I started packing up my boxes, the emotions came on hard. I was moving somewhere I'd always wanted to live (woo-hoo!), but I was also leaving behind family and friends. And my parents were selling my childhood home. And I was going to have to navigate life in a dorm. Yes, this was college, not a unique experience, but still—these chaotic feelings did a number on my mental health and made me pretty darn anxious. But that’s normal when you're going through changes, whether good or bad, rare or run-of-the-mill.
Change impacts your brain on a chemical level. “Novelty is a big driver of learning and synaptic change,” says Alison L. Barth, PhD, a professor of life sciences at Carnegie Mellon University. “Your brain works differently when everything seems new.” The positive side of it all: Your brain was built for this. “Making a change isn't an inher-ently bad or stressful thing that your brain can’t manage—it is liter-ally its job,” says Rachel Proujansky, PsyD, director of trauma services at the Center for Motivation and Change in New York City.
This story is from the Spring 2025 edition of Women's Health US.
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