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How Bacteria Signal to Survive Antibiotic Attacks?
Scientific India
|May-June 2025
In the natural world, communication is often a key to survival—whether in animal herds, insect swarms, or even microbial colonies.
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Bacteria, though single-celled and microscopic, are no exception. When facing life-threatening challenges like antibiotics, they deploy surprisingly advanced signaling systems to warn their peers and mount a collective defense.
A prime example is Streptococcus pneumoniae, a bacterium responsible for serious infections such as pneumonia, meningitis, and sepsis. Increasingly resistant to antibiotics, this microbe has become a focal point for scientists trying to understand how resistance spreads so effectively through bacterial populations. One clue lies in a process known as competence a temporary state that allows bacteria to absorb DNA from their surroundings. This foreign genetic material often contains resistance genes, giving recipient cells the tools they need to withstand antibiotic treatment.

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