Members of the drivers' union Aslef are striking for 24 hours on the majority of services in England and some cross-border routes into Scotland and Wales, leaving only 40% of trains running.
Some networks will run no trains at all, including Avanti West Coast, Chiltern Railways, Cross Country, East Midlands Railway, Great Northern, Southern, Southeastern, Thameslink and Northern, while others will offer a reduced timetable.
The strike will cause disruption for anyone trying to travel to the weekend's big sporting and cultural events including the FA Cup final between Manchester City and Manchester United at Wembley Stadium, the Epsom Derby and the final leg of Beyoncé's Renaissance tour in London, as well as affecting families planning end-of-half-term trips.
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