United have won one of their last seven matches and have failed to score in the last four for the first time since November 1992.
Alejandro Garnacho squandered a one-on-one with West Ham keeper Alphonse Areola with the game goalless in the first half and West Ham took the lead through Jarrod Bowen in the 72nd minute.
Rasmus Hojlund has failed to score in 14 Premier League appearances, winger Antony is without a goal since April and Garnacho's only league goal was his overhead kick at Everton last month.
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