Multipurpose fluid bed processors from Romaco Innojet in use at Klocke Pharma-Service GmbH

When it comes to producing and coating granulates, contract manufacturer Klocke Pharma-Service GmbH puts its trust in fluid bed technology from Romaco Innojet. With its wide range of applications, short processing times, linear scalability, sparing use of raw materials and reliable, energy-efficient production processes, the VENTILUS technology is tailor-made for the requirements of a contract manufacturing organisation

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The Klocke Group is one of Europe's leading contract manufacturing and packaging suppliers. Klocke Pharma-Service GmbH, at home in Appenweier in south-west Germany, processes a variety of raw materials into powder granulates and pellets, mainly for compression into tablets. The contract manufacturer first started using VENTILUS fluid bed processors from Innojet, a Romaco Group company, in 2014 and has continuously enlarged its stock of these technologies ever since.

Klocke presently has six Innojet-built fluid bed processors at its disposal for carrying out wet granulation processes with aqueous and solvent-based binder media as well as for drying and pellet coating. In addition to a VENTILUS® pilot plant for batch sizes up to 50 litres, three production plants for up to 400 litres and two for up to 800 litres are in use today. The systems are designed to be compatible as regards product filters and spare parts, and upscaling from a smaller processing machine to a larger one is a simple matter.

“The VENTILUS fluid bed processors from Romaco Innojet helped us achieve a technological leap forward”, reports Alexander Pergande, Managing Director Operations at Klocke Pharma-Service. “The uniform flow conditions in the machines and the precise bottom spray technology mean we can produce granulates with a more homogeneous particle size distribution and hence better flowability, leading to higher tabletting speeds. What's more, our service portfolio has been expanded on the basis of this technology, and we're now also in a position to coat pellets or film-coat micro-tablets, which we couldn't do with top spray technology.”

Patented air flow bed technology