COMPACTROL®: A new age diluent for pharma and nutra industries

COMPACTROL®, specially processed calcium sulfate dihydrate powder, is suitable as a filler in tablets manufactured by direct compression. It is also an effective diluent for two-piece hard capsule filling application

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COMPACTROL is calcium sulfate dihydrate, an inorganic material, which is naturally derived. It is roller compacted and size classified to obtain a median particle size and size distribution ideal for pharmaceutical and nutraceutical applications.

COMPACTROL® - Calcium Sulfate as a diluent has an advantages of possessing low concentration of unbound moisture as well as having a low affinity for atmospheric moisture. These are required features for any excipient material to be combined with a water sensitive drug.

The bound water of calcium sulfate is not released until a temperature of approximately 800C is reached.

Such bound water is usually unavailable for chemical reaction. Such excipients containing tightly bound water and having a low remaining moisture demand may be vastly superior to an anhydrous diluent, which has moderate to high moisture demand[4].

Types of calcium Sulfate [3].

There are three types of calcium sulfateA) Calcium sulfate Dihydrate is used in the formulation of tablets and capsules. In granular form, it has good compaction properties and moderate disintegration properties.

B) Calcium sulfate hemihydrate is used in the preparation of plaster of Paris bandage, which is used for the immobilization of limbs and fractures; it should not be used in the formulation of tablets or capsules.