Intentar ORO - Gratis
Chromatographic processes to detect incompatibilities
Chronicle Pharmabiz
|November 27, 2025
ONE of the significant challenges facing nowadays by the drug making companies is the ability to produce a stable pharmaceutical product.
Several active pharmaceutical ingredients can respond unstably to oxidation, moisture or pH, affecting both the stability of the drug and the final formulation.
To achieve drug products with both superior quality and purity, there are several chromatographic processes developed by innovative companies. These processes remove impurities from pharmaceutical excipients without changing the fundamental structure of excipients in any way.
Chromatography is a primary analytical technique used to detect drug and excipient incompatibilities. It is highly valued in pre-formulation and formulation development studies due to its high resolution, sensitivity and ability to identify and separate individual components in a complex mixture, including potential degradation products.
Reactive impurities in pharmaceutical excipients could cause drug product instability and it will lead to decrease product performance, loss in potency, and/or formation of potentially toxic degradants.
The levels of reactive impurities in excipients may vary between lots and vendors.
Screening of excipients for these impurities and a thorough understanding of their potential interaction with drug candidates during early formulation development ensure robust drug product development.
The removal of impurities provides a range of added value to the pharmaceutical manufacturing companies containing enhanced active pharmaceutical ingredients stability, improved oxidative stability, reduced cellular irritation, enhanced skin permeation and reduced taste impact.
This process has been possible to eliminate many of the polar and oxidative impurities that are normally present in pharmaceutical pharmacopoeia grade ingredients. This process does not alter the chemical structure of the pharmaceutical excipients.
Esta historia es de la edición November 27, 2025 de Chronicle Pharmabiz.
Suscríbete a Magzter GOLD para acceder a miles de historias premium seleccionadas y a más de 9000 revistas y periódicos.
¿Ya eres suscriptor? Iniciar sesión
MÁS HISTORIAS DE Chronicle Pharmabiz
Chronicle Pharmabiz
NABL issues guidance on criteria for accreditation of medical imaging labs
THE National Accreditation Board for Testing and Calibration Laboratories (NABL) has issued guidance on specific criteria for accreditation of Medical Imaging-Conformity Assessment Bodies (MI-CAB) or medical imaging labs.
2 mins
February 5, 2026
Chronicle Pharmabiz
Govt imposes MIP for three APIs
THE Union ministry of commerce and industry has imposed Minimum Import Price (MIP) for three APIs - penicillins and its salts, amoxycillin and its salts, and 6-APA - restricting imports of these products valued under the MIP for a period of one year.
1 mins
February 5, 2026
Chronicle Pharmabiz
Panel asks MoA to integrate allopathy and Ayush
THE Parliamentary Panel on Health and Family Welfare has asked the Ministry of Ayush to work towards integrated healthcare facilities with collaborative synthesis between allopathy and Ayush systems of medicine.
1 mins
February 5, 2026
Chronicle Pharmabiz
Pharma assns explore investment opportunities in UP
IN order to explore investment opportunities in the growing Uttar Pradesh (UP) pharma industry, a high-level delegation of pharma associations like the IDMA, the Indian Pharmaceutical Alliance (IP Alliance) and the Organisation of Pharmaceutical Producers of India (OPPI) met Chief Minister (CM) of Uttar Pradesh Yogi Adityanath.
2 mins
February 12, 2026
Chronicle Pharmabiz
AI medical language tools changing healthcare access: Expert
ARTIFICIAL intelligence (AI)à supported medical language tools, today, convert technical terms into simpler explanations for patients with physical and cognitive disabilities.
1 mins
February 5, 2026
Chronicle Pharmabiz
Apollo Hospitals inks MoU with Roche Diagnostics
APOLLO Hospitals Enterprise grated healthcare provider, has announced an initiative to better leverage artificial intelligence (AI) to foster innovation, enhance patient care, and expedite clinical processes.
1 mins
February 5, 2026
Chronicle Pharmabiz
India-EU FTA boosts innovating med-tech sector
THE India-EU Free Trade Agreement provides substantial benefits for the pharmaceutical and medical devices sectors, subject to phased implementation and final ratification details.
1 min
February 5, 2026
Chronicle Pharmabiz
'India-EU FTA has potential to be a game changer for pharma'
THE India-EU FTA has the potential to be a game-changer for Indian pharma and medtech companies.
2 mins
February 5, 2026
Chronicle Pharmabiz
PAN India CME reinforces evidence-based nutrition
PHYSICIANS Association for Nutrition (PAN) India has brought in a multidisciplinary approach to bridge research evidence and clinical practice in preventive health and nutrition.
1 min
February 5, 2026
Chronicle Pharmabiz
Govt to do away with provisional regn of EC
As part of the series of amendments notified or proposed under the NDCT Rules 2019 to simplify the procedures and enhance ease of doing business, the Union Health Ministry has proposed another amendment to do away with requirements of granting of Provisional Certificate for registration of Ethics Committee (EC) related to biomedical and health research.
1 min
February 12, 2026
Listen
Translate
Change font size

