Dr Gajendra Singh, Assistant Professor, Indian Institute of Technology Mandi, India
Dry powder inhalers (DPI) remain a vital part of our healthcare system due to their extensive use caused by a large number of respiratory patients globally. However, despite their wide use, their inherent inefficiency leads to drug wastage, poor therapy, and high costs to the end-user.
These devices have also been used for the delivery of antibiotics with dry powders also having the ability to be used for nasal inspiration for the treatment of local as well as systemic disorders.
Precise particle size control
When a person inhales orally through a DPI, the air starts moving at high speed within the device. The air lifts the powder sitting inside the DPI or helps to move a capsule that contains the powder. This highspeed airflow eventually helps to aerosolise the drug within the DPI chamber. The chamber, designed to intensify the turbulence of the inhaled air, facilitates the collision of particle clusters with the chamber walls, helping them to “de-agglomerate” into fine particles of the size of a few microns (this is what we want to get to the lungs). Following this complex process, the fine aerosol exits the device and travels to the lungs through the patient’s mouth and airway.
هذه القصة مأخوذة من طبعة BioSpectrum Asia Sep 2023 من BioSpectrum Asia.
ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 8500 مجلة وصحيفة.
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هذه القصة مأخوذة من طبعة BioSpectrum Asia Sep 2023 من BioSpectrum Asia.
ابدأ النسخة التجريبية المجانية من Magzter GOLD لمدة 7 أيام للوصول إلى آلاف القصص المتميزة المنسقة وأكثر من 8500 مجلة وصحيفة.
بالفعل مشترك? تسجيل الدخول
New South Wales government injects $5M for critical research to address Silicosis crisis
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What's APAC's Recipe of Success in CLINICAL TRIALS MARKET?
Asia-Pacific APAC) is emerging as one of the most promising and resilient markets for clinical trials. According to a report by Clinical Trials Arena, between 2017 and 2022, the region posted growth in clinical trials of around 10 per cent, outstripping growth in other major regions including the US, Europe and the rest of the world RoW). Asia’s growth far exceeded the overall average figure of 5.3 per cent per year. As of 2023, the number of trials reached 14,346 in APAC. Let's delve into the thriving clinical research landscape in the region and explore the trends driving its growth.
From Haematologic to Autoimmune DiseaseThe CAR-T Therapy Second Revolution
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"Biotech startups still need support in terms of talent, and resources to bring their innovations to market"
Raymond Chow has recently stepped in as the Vice President, Asia Pacific at USheadquartered Cytiva, a global provider of technologies and services for biological therapies, formerly known as GE Healthcare Life Sciences.
"We are exploring opportunities to collaborate with startups and incubators"
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With a cumulative total of almost 478,000 globally registered trials from the year 2000 to 2023, and growing at around 10 per cent a year in the last five years, the pharmaceutical industry continues to invest in clinical trials as the gold-standard test of therapeutic safety and efficacy. In addition, as the world’s economies and populations move in new directions, the share of non-US trials has reached 54 per cent, a trend that is likely to continue, driven by demographics and epidemiology. As the pace accelerates, trial managers and clinicians face a significant challenge: the explosive growth of data volumes. To succeed in the future, clinical trials need to increase efficiency and better utilise clinical trial data to support informed clinical and operational decision-making.
How APAC Has Turned into Clinical Trial Behemoth
From being a consistent participant in clinical trial conduct worldwide, the APAC has emerged as a major power. A number of causes, including the region's thriving drug development innovation and the ongoing presence of international pharmaceutical corporations conducting multiregional studies, are driving this growth.
