Orange juice research squeezes out new clues for heart health

Consuming this beverage regularly helps control blood pressure, reduce inflammation and improve heart-related health markers. By David C Gaze

- David C Gaze

A recent study has shown that regular orange juice consumption can influence the activity of thousands of genes inside our immune cells.

Many of these genes help control blood pressure, calm inflammation and manage the way the body processes sugar, all of which play an important role in long-term heart health.

The study followed adults who drank 500ml of pure pasteurised orange juice every day for two months. After 60 days, many genes associated with inflammation and higher blood pressure had become less active.

These included NAMPT, IL6, IL1B and NLRP3, which usually switch on when the body is under stress. Another gene known as SGK1, which affects the kidneys' ability to hold on to sodium (salt), also became less active.

Such changes match previous findings that daily orange juice drinking can reduce blood pressure in young adults.

This is noteworthy because it offers a possible explanation for why orange juice has been linked to better heart health in several trials. The new work shows that the drink does not simply raise blood sugar. Instead, it appears to trigger small shifts in the body's regulatory systems that reduce inflammation and help blood vessels relax.