PROSOLV® 730: Directly compressible carrier for lipophilic ingredients

Nearly 90 % of molecules in the discovery pipeline and 40 % of drugs with market approval are poorly water soluble. Poor aqueous solubility can lead to low bioavailability resulting in insufficient plasma levels. Oil-based preparations of these APIs, as well as oily APIs in general, present challenges in terms of solid dosage form manufacturing. PROSOLV® 730 was designed to provide a solution to the formulation of BCS class II and IV APIs. It enables the formulation of lipidic APIs or API-loaded lipid systems by facilitating the adsorption of oil, creating a free-flowing, compactible system that can be further formulated. PROSOLV® 730 is a co-processed, high-functionality excipient comprising MCC SILICA COPOVIDONE

- Mr. Suyesh Kale

Nearly 90% of molecules in the discovery pipeline and 40% of drugs with market approval are poorly water soluble.

Poor aqueous solubility can lead to low bioavailability resulting in insufficient plasma levels.

Oil-based preparations of these APIs, as well as oily APIs in general, present challenges in terms of solid dosage form manufacturing.

PROSOLVⓇ 730 was designed to provide a solution to the formulation of BCS class II and IV APIs. It enables the formulation of lipidic APIs or APIloaded lipid systems by facilitating the adsorption of oil, creating a free-flowing, compactible system that can be further formulated.

PROSOLV® 730 is a coprocessed, high-functionality excipient comprising MCC SILICA COPOVIDONE

Specific surface area

PROSOLV 730 presents a 70 plus times greater specific surface area than Microcrystalline Cellulose.

Physical Properties of PROSOLV® 730

• High oil binding capacity

• White, free-flowing powder

• Chemically inert

• Non-soluble

• Excellent compactability

• Enhanced lubrication efficiency

• Improved blending properties

• Over 70 times greater specific surface area than regular Microcrystalline Cellulose (MCC)

• Coprocessed excipient with no chemical bonding between ingredients