Many men also see hair changes related to testosterone. Regional hair overgrowth can result in scary-looking eyebrows, or furry ears. However, the greatest concern is hair loss. There are numerous causes for hair loss, but this article deals primarily with testosterone-related hair loss, called androgenetic alopecia (AA). AA commonly results in loss of hair in an ever-growing patch, typically from the crown of the head. About half of all men (and a fair number of women) will develop “male pattern balding.” For some, this may start in their early 20s, while others will be spared any noticeable hair loss until their mid-50s.
Bodybuilders and other athletes who have used anabolic-androgenic steroids (AAS) and are predisposed to hair loss often see an acceleration during AAS cycles. Testosterone is an androgen, but in the body it can be converted into a more androgenic form called DHT via an enzyme called 5-alpha reductase (5AR); conversely, it can be metabolized into an estrogen via a separate enzyme group called aromatase. During natural testosterone production, an epimer called epitestosterone is produced in near-equivalent amounts. Epitestosterone has anti-androgenic properties, so it probably balances out the effects of testosterone. AAS users suppress natural testosterone production (and thus epitestosterone production), so they lose that protective “check and balance.” The AAS that cause the most pronounced hair loss are those based upon the DHT structure or those that do not aromatize easily; Winstrol and Anadrol 50 are notorious for this effect.
So, it is an inevitable fact of life that half of all men (and possibly a higher percentage of AAS users) will have to deal with the comb-over? Thankfully, not; there is research old and new that offers hope. In the last few decades, relatively effective and scientifically based treatments became available. Of course, there is always HairClub, formerly Hair Club for Men, but there is something “right” about regrowing one’s own hair. It is a sign of youth and health to the masses.
The first hair-loss drug to be approved was minoxidil (Rogaine). This drug was originally developed to treat high blood pressure, but the “side effect” was discovered incidentally when patients commonly reported hair regrowth. Despite the early promise, minoxidil’s results have not lived up to the “miracle drug” status. It does work in providing hair regrowth to lesser or greater effect in about two out of three men who are in the early stages of hair loss; women suffering from androgenetic alopecia experience better and more consistent results. Of course, women are less affected due to higher estrogen and lower DHT concentrations.
Minoxidil works best on the crown of the head, and is not as effective in treating frontal hair loss (i.e., receding hairline). Its effects are not permanent, requiring daily or twice-daily application. Minoxidil is available as an over-the-counter product, so it is readily accessible. Minoxidil appears to push hair follicles past the “resting” stage (telogen), back into the growth phase of the hair life cycle (anagen). It is presumed that improved blood flow to the scalp may be one route of effect; increased intracellular calcium is another proposed effect.
Another shampoo available over-the-counter has been shown to be nearly equivalent to minoxidil; however, it has not been submitted to the FDA for approval as a hair-loss treatment. This is likely a financial issue, rather than a clinical issue, as the active ingredient (ketoconazole) has been known to affect hair growth for many years. Therefore, any product would not be eligible for patent protection. However, as consumer magazines have reported this effect repeatedly over the years, it is likely that much of the demand for Nizoral and other ketoconazole-based shampoos is for treating hair loss. Ketoconazole is an antifungal drug, and has also been shown to lower testosterone and reduce inflammation. All three of these functions may aid in promoting hair growth.
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TESTOSTERONE AND HAIR LOSS: How to Get Ahead
The simple fact is that most men are concerned about their looks; for the bodybuilder and fitness enthusiast, appearance is a strong factor in one’s satisfaction. It is undeniable that testosterone (T) directly impacts the physical health, function, and appearance of a man; as well, one’s mental health and cognitive abilities. In the chronology of life, testosterone’s effects produce milestones that easily identify the stages of life: the ultrasound’s shadow of a penis during pregnancy; a wispy mustache during adolescence; a deep voice during adulthood; and with its decline late in life, the loss of muscle, and erectile dysfunction.
TESTOSTERONE AND GH RESPONSES: FREE WEIGHTS VS. MACHINES
All forms of resistance training provide a stimulus that induces an anabolic-hormonal response, which contributes to adaptations associated with weight training such as muscle growth and strength. More precisely, weight training causes an increase in the two most prominent muscle-building hormones, testosterone and growth hormone (GH). Testosterone drives muscle growth by stimulating muscle protein synthesis and inhibiting muscle protein degradation. GH triggers greater muscle growth primarily by stimulating the production of insulin-like growth factor 1 (IGF-1), which has been shown to also potently stimulate muscle growth by increasing muscle cell protein synthesis.
Monetizing Social Media
NEW RESEARCH: INTERMITTENT FASTING INCREASES AB FAT
Intermittent fasting, often referred to time-restricted eating, has become the latest diet craze not only for weight loss but also for enhancing health. Everyone from well-known celebrities to everyday, average people are trying intermittent fasting and claiming it is successful.
Lose Fat and Boost TESTOSTREONE
Every bodybuilder or athlete understands too much body fat can be detrimental. For the bodybuilder, too much body fat detracts from the physique. The athlete can’t carry too much body fat because it decreases speed and quickness, thus diminishing athletic performance. Although fat tissue can be physically unappealing to the bodybuilder while negatively influencing athletic prowess, fat cells also perform an additional function that can negatively impact the athlete and bodybuilder by drastically decreasing the production of the muscle-building hormone testosterone.
Lorie Forman LOOKING Great at 48!
Lorie Forman turned pro as a Bikini competitor at the 2015 NPC Universe, and was the first woman to score three pro card wins in one show and in every division she entered: Bikini Open, Masters Over 35 and Masters Over 40 and took home the Masters overall. But that’s not Lorie’s only remarkable achievement: at age 48, she looks and feels like a twenty-something athlete.
BRAD ROWE IFBB Pro and Trainer to the Stars!
Success in bodybuilding is often assumed to correlate with contest wins and high finishes at the Mr. Olympia and Arnold Classic. Yet there are many other avenues available today, some far more lucrative than relying on prize money or even supplement contracts. One man who exemplifies the level of success possible beyond the stage is Brad Rowe. Though he was no slouch on stage, he gained far more visibility appearing in national commercials for companies like GoDaddy, Coca-Cola, Kia, Taco Bell and Dannon Oikos, some of which aired during Super Bowls. More recently, Brad’s prominence as an elite personal trainer got a major boost when Mike Tyson hired him to be his full-time strength and conditioning coach, training him for his 2020 comeback fight at age 54 with Roy Jones Jr. I spoke with fellow native New Englander Brad about why he stepped away from competing, how he became part of Mike Tyson’s training camp, and his major project that stands to make him one of the biggest players in the growing field of anti-aging and cutting-edge athletic performance.
Meet Thomas Connelly, DDS, Dentist to the Stars and IFBB Pro
A Tribute to THE INCREDIBLE ANDY HAMAN
In my 35 years as Publisher and Editor-in-Chief of Muscular Development, I never met a guy like Andy Haman. We had one thing in common, we both wrestled in college. I went to Indiana State University on a wrestling scholarship and Andy went to the University of Iowa and became a championship wrestler. In 2007, Andy won the super heavyweight class at the NPC Masters bodybuilding championships, earning his pro card.
Classic Training Camp
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HOW FAST IS WARP SPEED?
WHERE WE STAND ON AN EFFECTIVE COVID -19 VACCINE
In a world where a keyboard can cause more damage than a gunship, a corporate cyber attack victim and its insurers have gone to court to figure out what’s covered and what’s not
How EpiPen Became A Hit
Mylans marketing turned the allergy device into a must-have.
भारत की पांच फर्मों को कोविड दवा के लाइसेंस
मर्क ऐंड कंपनी की मोलनुपिराविर, ओरल एंटीवायरल दवा है जो अभी तीसरे चरण के ट्रायल में है
“We see opportunities across Asia with India as one of the key markets”
Headquartered in Sweden, Bio-Works Technologies AB carries out R&D, manufacturing and supply of agarose-based resins used to separate proteins and other biomolecules.
“Peptide purification market is underserved by traditional resin suppliers”
« Jonathan Royce, Chief Executive Officer, Bio-Works Technologies AB, Sweden
DÍA DEL CUIDADOR ¿QUIÉN CUIDA DE LOS QUE CUIDAN?
Concentran su energía y tiempo en atender las necesidades de otros y, a menudo, se olvidan de las propias. La pregunta es inevitable: ¿quién presta atención a los cuidadores no profesionales?
DÍA DEL CUIDADOR ¿Quién cuida de los que cuidan?
Concentran su energía y tiempo en atender las necesidades de otros y a menudo se olvidan de las propias. La pregunta es inevitable: ¿quién presta atención a los cuidadores no profesionales?
Merck opens largest M Lab collaboration center in Shanghai
Merck, a leading science and technology company, opened its M Lab Collaboration Center in Shanghai, the company’s largest of nine centers worldwide.
“Merck is currently supplying key products and services to over 45 COVID-19 vaccine programmes around the world”
Asia Pacific Life Science business of Merck develops improved and enhanced technologies from biopharmaceutical therapies to cutting-edge systems for scientific research and production. Responding to COVID-19 outbreak, Merck’s BioProcessing unit is engaged in consolidating and supplying raw materials along with characterization and detection of vaccine research products. Merck actively evaluates and leverages business continuity plans for COVID-19 vaccines and therapies development. Merck’s SARS-CoV-2 detection, characterization, vaccine and therapy production capabilities are leveraged at the Jenner Institute for the development of Oxford vaccine. Prioritizing on crucial timeline Merck’s advanced upstream and downstream portfolios target faster yield and productivity to support and expedite the need of an hour. BioSpectrum Asia spoke with Benoit Opsomer, Vice President & Head of BioProcessing, Asia Pacific, Life Science business at Mercato explore the company’s commitment towards researchers, developers and manufacturers to combat COVID-19 pandemic.