PROSOLV® 730: Directly compressible carrier for lipophilic ingredients

Nearly 90% of molecules in the discovery pipeline and 40% of drugs with market approval are poorly water soluble.

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Poor aqueous solubility can lead to low bioavailability resulting in insufficient plasma levels.

Oil-based preparations of these APIs, as well as oily APIs in general, present challenges in terms of solid dosage form manufacturing.

PROSOLV 730 was designed to provide a solution to the formulation of BCS class II and IV APIs. It enables the formulation of lipidic APIs or API-loaded lipid systems by facilitating the adsorption of oil, creating a free-flowing, compatible system that can be further formulated.

PROSOLV 730 is a co-processed, high-functionality excipient comprising MCC SILICA COPOVIDONE

Specific surface area PROSOLV 730 presents a 70 plus times greater specific surface area than Microcrystalline Cellulose.

Physical Properties of PROSOLV® 730

◆ High oil binding capacity
◆ White, free-flowing powder
◆ Chemically inert
◆ Non-soluble
◆ Excellent compatibility
◆ Enhanced lubrication efficiency
◆ Improved blending properties
◆ Over 70 times greater specific surface area than regular Microcrystalline Cellulose (MCC)
◆ Coprocessed excipient with no chemical bonding between ingredients

Lipophilic actives have practically no solubility in water. They can be dissolved, however, in many non-aqueous media, including a wide range of different oils and organic solvents.

PROSOLV® 730 readily adsorbs and integrates oily APIs or API dissolved in non-aqueous liquids.

Oil-loaded PROSOLV® 730 is a free- flowing powder that is suitable for capsule filling as well as for direct compression of tablets.