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LIVE LONG AND PROSPER

Bangkok Post

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May 20, 2025

A longevity expert’s five tips for ageing well

- MOHANA RAVINDRANATH

LIVE LONG AND PROSPER

About two decades ago, a California research team observed a striking phenomenon. While a majority of older adults have at least two chronic diseases, some people reach their 80s without major illness.

The researchers suspected the key to healthier ageing was genetic. But after sequencing the genomes of 1,400 of these ageing outliers — a cohort they called the “Wellderly” — they found almost no difference between their biological makeup and that of their peers. They were, however, more physically active, more social and typically better educated than the general public.

That genes don’t necessarily determine healthy ageing is “liberating”, and suggests that “we can pretty much all do better” to delay disease, said Dr Eric Topol, a cardiologist and the founder of the Scripps Research Translational Institute, which ran the Wellderly study.

Topol is a prominent molecular scientist who has published 1,300 research articles, has written multiple books and has several hundred thousand followers across social media and his newsletter. His newest book, Super Agers: An Evidence-Based Approach To Longevity, delves into the rapidly evolving science of ageing.

In the book, Topol writes that tools like biological age tests and increasingly sophisticated health risk prediction could eventually paint a clearer picture of how we're ageing.

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