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Study finds new target for treating heart failure
YUGMARG NEWSPAPER
|25-06-2025
As society ages, the number of patients suffering from heart-failure">heart failure grows significantly. Fibrosis, or excessive growth of fibrotic tissue in the heart, has been linked to the advancement of heart-failure">heart failure. A group from Nagoya University Graduate School of Medicine in Japan discovered an enzyme called protein kinase N (PKN) that controls cardiac fibrosis.
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The enzyme converts heart fibroblasts to myofibroblasts, putting the heart's integrity at risk. Deleting this enzyme reduced ventricular dysfunction, indicating that anti-PKN therapies are a prospective therapy for protecting patients from heart-failure">heart failure. The findings were published in Nature Communications.
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