Faster time to market with Continuous Direct Compression

Development and production using Continuous Manufacturing

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The production of medicines and food supplements is experiencing a real innovation boost thanks to Continuous Manufacturing processes. For a long time, manufacturers hesitated in the face of cost-intensive conversions, time-consuming revalidation and complex systems with large space requirements. However, Continuous Manufacturing is now proving that endto-end production can also be space-saving, uncomplicated and economical. With the FE CPS, Fette Compacting is underlining this development and at the same time positioning itself as an integrated process partner.

In order to make continuous manufacturing more economically attractive, Fette Compacting fundamentally reviewed the concept of continuous direct compression a few years ago. The original approach was still strongly oriented towards established principles of pharmaceutical processing and the combination of existing systems. In order to fully utilize the advantages of continuous direct compression, it was necessary to rethink the entire process and system design.

The resulting processing system FE CPS (Continuous Processing System) establishes a reliable, powerful and highly flexible technology for the continuous production of pharmaceutical and nutraceutical products. The principle of Direct Compression enables the immediate transfer of the powder: it is transferred from the dosing-mixing unit directly to the tablet press via a flexible transport system (Fig. 1). Unlike conventional processes with wet or dry granulation, this eliminates several process steps, significantly reducing space requirements, energy consumption and overall costs. The developers designed the system for a wide range of application scenarios: It processes a wide range of ingredients with a flexible throughput of between five and over 200 kilograms per hour.

Inline quality control