"Continuous innovation and adherence to global quality will be key to maintaining India's growth in pharma exports"

The Indian Pharmaceutical Industry is celebrating an unprecedented milestone, with exports reaching a staggering $25.3 billion by the end of the first quarter of the 2023 fiscal year.

30 Young CEOs Closely Contest the Best Bio CEO Awards

The race was on among young biotech CEOs for top position in 2023 Best Bio CEO awards organised by Global Bio and Investment media in Taipei, Taiwan.

The Changing Face of Chromatography

From cutting-edge gene therapies to groundbreaking MRNA vaccines, innovative approaches hold tremendous promise for treating and preventing diseases. However, their development and production pose unique challenges that demand equally innovative solutions. Let’s look at how chromatography, a foundational technique in biopharmaceutical manufacturing, is keeping pace with these new therapies and explore the latest developments in the chromatography market.

Pushing The Age Barrier

In 2022, 1 in 7 individuals in Asia Pacific were aged 60 or older. This demographic trend is accelerating, with projections suggesting that by 2050, 1 in 4 people in the region will fall into this age group, according to the United Nations, Economic and Social Commission for Asia and the Pacific (ESCAP), 2022.

Disruptive Technologies and New Industry Initiatives for Diabetes Management

Asia will continue to be a large and rapidly growing market for diabetes care technologies. To be competitive and successful in the aggressive market with numerous large and startup companies, players will need large funds, a broad portfolio with desirable differentiators and a strong distribution network. Low-cost products, subscription-based solutions, reimbursement policies and training of patients and physicians will be required to promote the adoption among low income and middle-income regions. Large players are very intent on tapping the large market potential in Asia. Many global companies have set up local presence in Asian countries and local production through OEM partners in the countries to bring down the cost of their solutions, and more companies are expected to follow.

"Computer-Aided Diagnosis provided by Al needs to gain trust from doctors"

In November 2022, The Industrial Technology Research Institute (ITRI), Taiwan’s prominent high-tech research institution, launched Point-of Care AI-DR, the first AI-assisted system integrated into commonly used handheld and desktop fundus cameras in healthcare settings for diabetic retinopathy (DR) and diabetic macular edema (DME) detection. Dr Lee Ya-wen, Technical Manager, ICL, ITRI sheds more light on ITRI’s Point-of-Care AI-DR system, opportunities and challenges of AI-assisted diagnostic systems etc. Edited excerpts:

Prediabetes can significantly impact quality of life

Even though prediabetes is a leading risk factor for diabetes and may predict cardiovascular disease and increased mortality, the degree of unawareness is very high with up to 85 per cent not being aware of their condition. Early diagnoses can help enable better treatment outcomes, better quality of life, and damaged nerves can be regenerated if nerve care damage has not progressed too far.

Addressing Diabetes-related Complications

Southeast Asia is currently home to 90 million adults diagnosed with diabetes, and this number is expected to reach 113 million by 2030, according to the International Diabetes Federation (IDF) Diabetes Atlas 2022. Out of these 90 million, 46 million remain undiagnosed.

The Better The AI Gets, The Harder It Is To Ignore

Hong Kong based Insilico Medicine, a pioneer in AI-based drug discovery, has made significant strides in recent years. Two of their candidates have reached clinical trials, with INS018-055 leading the pack as the first AI-discovered drug designed by generative AI to enter phase 2 clinical trials for idiopathic pulmonary fibrosis (IPF). Back in 2014, when the company began, AI for drug discovery was relatively unheard of, but now it’s an indispensable part of the drug discovery process. Insilico’s partnerships with major pharmaceutical firms like Janssen underscore the growing importance of AI in this field. Dr Alex Zhavoronkov, Founder and CEO of Insilico Medicine, sheds light on the industry’s evolving response to AI in drug discovery, partnerships, regulatory reforms etc. and also shares the company’s future plans. Edited excerpts:

SK bioscience, Vaxxas collaborate to develop needle-free patch delivery platform of typhoid vaccine

South Korea-based SK bioscience has entered into a collaboration agreement with Vaxxas, an Australian biotechnology company developing a unique vaccine patch platform technology, to develop a second-generation typhoid conjugate vaccine with support from Wellcome.

Interacting with Startups to Tackle Mental Healthcare

The Asia-Pacific Economic Cooperation APEC), a government organisation for economic cooperation across APAC countries, reported that mental illness accounted for more than 20 per cent of the total years lost and less than 50 per cent of the people affected by mental illness received evidence-based treatment. To address these mental health concerns, startups in the APAC region have new technologies for improving awareness of mental health, maintaining the privacy of a patient, improving accessibility, and reducing unwanted hospitalisation. There is also a rise in mental wellness solutions in the form of phone apps and other digital platforms which will enable a paradigm shift towards preventive mental healthcare in the next few years. Let’s delve further.

What's Transforming Australia's Thriving Life Sciences Industry?

With research and development thriving, and demand for locally made biopharmaceuticals increasing in an effort to secure reliable medical supply chains, Australia has set its sights on becoming a global life sciences hub. As Australia heads towards becoming a global life sciences hub, the industry pledges opportunities for all stakeholders, solidifying its pivotal role in shaping the nation’s healthcare landscape.

"Lunit is poised to evolve from an Al-based medical imaging company into a pioneering provider of Al healthcare platform"

Lunit Inc, a pioneering player in South Korea’s medical imaging industry, achieved significant milestones in 2023. The company secured the EU MDR mark and unveiled its cutting-edge 3D breast screening product, known as ‘Lunit INSIGHT DBT.’ Notably, Lunit’s AI technology has been adopted by over 2,000 healthcare institutions worldwide, marking a major accomplishment. Lunit made noteworthy announcements, including their expansion into Saudi Arabia and Europe. Brandon Suh, the CEO of Lunit Inc., shares more about the company’s mission to combat cancer and advance medical image analytics. Edited excerpts;

"By harnessing the power of single-cell analysis, we can gain deeper understanding of various NCDs"

Single cell analysis is revolutionising fundamental biological research, paving the way for effective personalised treatments and precise interventions. By systematically investigating cellular heterogeneity, researchers are gaining unprecedented insights into gene mutations, cellular interactions, regulatory mechanisms, and molecular pathways that drive disease progression. BioSpectrum Asia spoke to Tony Acciarito, President, Asia-Pacific & Japan, Thermo Fisher Scientific to gain more insights into the future of this promising technology. Edited excerpts:

Is APAC Edging Closer to Clinical Application of Single-cell Tech?

Asia Pacific APAC) is expected to be a major contributor to the growth of single cell technology as the market is driven by factors such as the growing demand for personalised medicine, advancements in sequencing technologies, and the increasing use of single cell analysis in drug discovery. While Japan is currently the fastest-growing country in the APAC single-cell analysis market, Singapore, China, and India are showing significant progress in adopting this technology.

"Regulatory reforms and incentives implemented by Middle Eastern countries have simplified market entry for life sciences companies"

In May 2023, Virax Biolabs Group Limited, a UK-based diagnostics company specialising in viral disease detection and immune response diagnosis, inaugurated its regional headquarters at Dubai Science Park. This strategic move aims to facilitate the company’s expansion into the Middle East, enhance global operations through the attraction of local partnerships and talent. James Foster, CEO of Virax elaborates on the significance of this move and why the Middle East is an appealing destination for life sciences firms. Edited excerpts:

Big Pharma Sets Sights on Middle East

The Middle East, traditionally renowned for its prominence in the travel and oil and gas industries, is shifting its focus towards the life sciences sector. The region is actively forging numerous partnerships, initiatives, and programmes, and spending billions to establish itself as a major hub for life sciences. As the population of the region continues to grow and age, there is a clear and growing demand for locally manufactured medical treatments and products. Big pharma players are also making substantial inroads into the Middle East, with the Kingdom of Saudi Arabia (KSA), Qatar, and the United Arab Emirates (UAE) leading the way in these regional efforts. Areas such as rare diseases, genomics, personalised medicines, and pharmaceutical manufacturing have emerged as hotspots in the Middle East. Let’s delve deeper into the region’s endeavours to become a biotech powerhouse.

A LITHIUM CRISIS

It may sound strange, but it is going to be a car battery versus medicine conflict, at least in Japan. Recent news reports from Japan indicate the possibility of shortage of some life saving drugs due to growing use of electric vehicles. So, the dilemma is, do we want clean air at the cost of the suffering of some patients? This dilemma is caused by Lithium, also known as white gold.

Sirnaomics brings Dr Francois Lebel on board for clinical development

With presence in both US and China, Sirnaomics has announced that Dr Francois Lebel, an experienced biopharmaceutical industry executive, has been appointed as Senior Vice President for preclinical and clinical development of the Group.

South Korea offers customised treatment for lung cancer patients

A group of researchers at Pohang University of Science and Technology (POSTECH) in South Korea, along with researchers at Gradiant Bioconvergence, has recreated the internal environment of a lung cancer patient using a hydrogel derived from decellularised extracellular matrix (LudECM) obtained from porcine lungs.

BIO Asia-Taiwan 2023 attracts 100,000 visitors from 31 countries

The Taiwan Bio Industry Organization (Taiwan BIO) and the global Biotechnology Innovation Organisation (BIO) ignited Taiwan’s three-day conference BIO Asia-Taiwan 2023 from July 26 to 30 at the Taipei Nangang International Exhibition Center (TaiNEX 1 and TaiNEX 2).

Understanding Medicinal Drug Delivery Using Dry Powder Inhalers (DPIS)

For a long time, dry powder inhalers (DPI) have been used for treating asthma, and other respiratory diseases, by delivering medication directly to the lungs.

Regulatory Landscape of In Vitro Fertilisation (IVF) Across Asia

According to the World Health Organisation (WHO) data, approximately one in every six couples worldwide is impacted by infertility.

"Policies that help to add value to the R&D ecosystem are essential to empower Indian medical device sector"

OMRON Healthcare Manufacturing India (a subsidiary of OMRON Healthcare Corporation Japan) has begun the construction of its new plant in Chennai in May 2023.

"The APAC market is expected to witness the fastest growth of any radiopharmaceutical market worldwide"

Australian firm Telix Pharmaceuticals is pioneering advanced radiopharmaceuticals. Recently, the company achieved remarkable success with the global launch of Illuccix, their first commercial product for prostate cancer imaging in 2022.

"We need concerted action that brings together everyone's work to solve the CVD crisis"

In June 2023, the Asia-Pacific Cardiovascular Disease Alliance (APAC CVD Alliance) was established to address the increasing burden of cardiovascular disease in the region.

South Korea poised to become MEDICAL AI POWERHOUSE

When it comes to Al (Artificial Intelligence) in medical sciences - China and the USA dominate the field. However, South Korea has been steadily catching up. Home to renowned tech giants such as Samsung and LG Electronics, South Korea is positioning itself as a significant player in the medical Al domain. The country is making remarkable strides in deploying Al for medical imaging, diagnostics, drug development and healthcare. Let's look at South Korea's efforts in becoming a medical Al powerhouse.

Multipronged Approach Against Alzheimer's Disease

In July 2023, Eisai and Biogen received full traditional approval from the United States Food and Drug Administration (US FDA) for their Alzheimer's drug Leqembi (lecanemab-irmb). This drug is the first to target the disease's progression rather than merely addressing its symptoms.

"India has huge talent in generics, chemistry, biology, developing novel vaccines but not in novel drug discovery"

“India has huge talent in areas such as generics, chemistry, biology, developing novel vaccines like mRNA, mDNA etc. but not in novel drug discovery” said Dr Anandkumar, Co-Founder & CEO, Bugworks Research.

BioSpectrum India honours Bio & Health Sciences stalwarts

Leaders from the Indian Bio & Health Sciences industry were felicitated by India’s leading Bio & Health Sciences publication, BioSpectrum for their outstanding contribution over the past two years.