GH Decreases ABDOMINAL FAT and Increases Lean Mass
Muscular Development|September 2022
The Internet is overwhelmed with articles citing research about human growth hormone (HGH) and its effects on body composition. Many times, the population studied is a group suffering from a chronic disease or metabolic disorder; more relevant studies examining GH’s effects on essentially normal, healthy people are relatively few and far between.1,2 Nonetheless, several studies have looked at the use of GH in healthy people who are overweight, obese or abdominally obese to reduce body fat or more specifically, visceral fat.
Daniel Gwartney, MD
GH Decreases ABDOMINAL FAT and Increases Lean Mass

One would think with the generally accepted role GH plays in lipolysis (fat breakdown and release from fat cells) and the established benefit of GH in improving body composition, that researchers would begin looking to determine the therapeutic range rather than continuing to revisit the basic question. Of course, there is value to any well-designed study, as it may expose groups who might be more prone to adverse responses to GH therapy and clarifies indications and contra-indications for GH use. Another benefit to duplication of research is that results are either confirmed or if discrepancies are noted, then the impact of differences between the studies can be evaluated.

Effect on Visceral Fat Loss

One study on the degree of effect of GH on visceral (intra-abdominal) obesity in healthy, adult men was published in The Journal of Clinical Endocrinology & Metabolism.8 The researchers recruited men who were obese (BMI between 27 and 35) with a waistline measuring at least 40 inches. The men were otherwise healthy, had not experienced weight change over the last 12 months and had low-normal IGF-1 levels. The men were divided into the test subjects who received approximately 1mg GH/day (roughly 3 IU) and a control group who received placebo injections. GH (or placebo) was administered for six months and then the subjects were followed for six months offGH (or placebo) to see if any changes persisted after the drug was withdrawn. The GH dose was designed to result in serum IGF-1 levels slightly above the uppermost limit of the normal range. IGF-1 measurements halfway through the GH administration and at the end of GH use confirmed the dose did in fact result in this level of response.

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