“APAC is dynamic and rapidly evolving, with tremendous growth in R&D and attractive market conditions”

With cell and gene therapy (CGT) representing a major advancement in medical treatments by directly targeting the root causes of diseases at the cellular or genetic level, GlobalData’s latest report predicts the CGT market to be worth $76 billion by 2030.

- Dr Manbeena Chawla

Reports also reveal that the North America region captured the highest revenue share of the CGT market in 2024. To find out more about the new developments taking place in the CGT sector, particularly in the US, BioSpectrum Asia spoke with Amy C Hay, Chief Business Officer, Cell Therapy Manufacturing Center (CTMC), a joint venture between University of Texas MD Anderson Cancer Center and National Resilience, Inc. in the United States. Edited excerpts:

What are the current developments taking place at CTMC, and what are your major plans for the next five years?

CTMC, a joint venture between Resilience + MD Anderson Cancer Center, was founded in 2022 to accelerate driving life-saving cell therapies to patients. In just three years, CTMC expanded its pipeline, supporting both MD Anderson investigators and biotech companies to advance novel cell therapies through Investigational New Drug (IND)-enabling studies and FDA interactions.

CTMC’s portfolio has expanded from five to 13 partners, with a mix of 65 per cent biotechs and 35 per cent academic. CTMC has also submitted and cleared eight IND’s, all delivered on or ahead of schedule. Notable products include Obsidian Therapeutics’ novel tumour-infiltrating lymphocyte (TIL) therapy, OBX-115, and Invectys’ lead engineered human leukocyte antigen A (HLA-G) targeting chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumours.

We have also collaborated with several companies to enable new technology in the field to be evaluated, utilised, and easily accessed by our customers. Current collaborators include Ori Biotech (automated cell therapy manufacturing) and Syenex (enhanced gene delivery systems).