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Your Favorite Scream King Is Back in Action

October 13, 2025

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Us Weekly

Nearly 30 years since he declared “My mom and dad are gonna be so mad at me!” as Stu — a.k.a. one of the original Ghostface killers — in 1996’s Scream, Matthew Lillard is reprising his role in the latest installment of the hit slasher franchise (set for Feb. 27).

- MOLLY McGUIGAN

Your Favorite Scream King Is Back in Action

But first, the actor, 55, is tackling a real-life scare in Exact Sciences’ new Cologuard test campaign. “I personally have seen the ravages of cancer. It’s a horrible disease,” he tells Us of the Scream-themed ad to raise awareness for colon cancer screenings.

“At the end of the day, if this little spot can inspire people to get tested, that’s a win for humanity, [and] we need all the wins we can get right now.” Here’s more from Lillard on his upcoming projects.

Did you have any hesitations about Stu coming back?

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