CUSHING'S DISEASE IN CANINES

Imbalance in cortisol hormone can lead to serious, life-threatening conditions

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Cushing's disease (also known as Cushing's syndrome or hyperadrenocorticism) is a condition where a dog's adrenal glands produce too much cortisol, a hormone that helps regulate many body functions.

The adrenal glands, located near the kidneys, make several important hormones, with cortisol being one of the most well-known. Imbalances in cortisol—whether too much or too little—can lead to serious and sometimes life-threatening health issues.

When cortisol levels are too high, dogs may show signs like drinking and urinating more than usual, increased appetite, panting, hair loss, and a potbellied appearance. This condition is fairly common, especially in middle-aged to older dogs.

What Causes the Disease?

There are three main types:

Pituitary-dependent (80 - 85% of all cases): A small, benign tumor of the pituitary gland in the brain may secrete excessive amounts of adrenocorticotropic hormone (ACTH), Which in turn over stimulates the adrenal glands, leading to increased cortisol production.

Adrenal-dependent: A tumor (benign or malignant) on one or both adrenal glands causes excessive cortisol production.

latrogenic: This condition arises from prolonged or excessive administration of oral or injectable corticosteroids. Although corticosteroids are often prescribed for good medical reasons, using them in excess can end up causing harm.