The Singapore Civil Defence Force (SCDF) said eight people were taken to hospital - four to Changi General Hospital, two to Tan Tock Seng Hospital, and two to KK Women's and Children's Hospital.
The police and SCDF said they were alerted to the accident at about 7.05am. It occurred at the junction of Tampines Avenue 1 and Tampines Avenue 4 and involved four cars, a van and a mini bus.
Various posts on social media said Temasek Junior College (TJC) student Afifah Munirah Muhammad Azril, a passenger in one of the cars, was one of the fatalities, and her family later confirmed she had died in the accident. The second fatality was a 57-year-old female passenger in the van.
In a video of the accident's lead up posted on the SG Road Vigilante Facebook group, a black car can be seen travelling at high speed past at least three vehicles. Moments later, the crash site at the junction is shown.
Photos of the accident's aftermath show a black car turned turtle with its doors flung open in the middle of the road. Another black car appears to be badly damaged, with its windscreen shattered and front bumper completely detached.
Debris from the crash is also scattered across the road.
Afifah, a first-year student at TJC, which is located at 2 Tampines Avenue 9, was on the way to take part in the annual TJC Road Run when the accident occurred.
In response to queries, TJC principal Liu Earnler said: "We are deeply saddened by the loss of one of our students.
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