Scotland Yard said a man in his 20s has been arrested after two officers - one male and one female were attacked in the Leicester Square area at around 6 am.
The female officer was stabbed through a vein in her arm suffering "massive blood loss", a police source told the PA news agency an injury which could be life-changing.
The male officer was stabbed three times in the neck and once in the chest but is expected to make a full recovery, Metropolitan Police Commissioner Sir Mark Rowley said.
A man in his 20s has been arrested on suspicion of causing grievous bodily harm and assaulting an emergency worker.
Speaking at Scotland Yard on Friday morning, Sir Mark said that both officers are now in stable condition.
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