The arrest of Khan who was ousted from power last year and has evaded arrest several times since came hours after he released a video message reiterating his allegations that Pakistan's powerful military establishment had tried to assassinate him twice.
Khan's arrest is the latest twist in a political and economic crisis that pits him against the military and the government, led by his successor, Shehbaz Sharif, whom Khan alleges conspired to remove him from power and make threats on his life, charges they deny.
Hours after his arrest, protests began to erupt across Pakistan, with the army accused of orchestrating his detention. More than 40 people were arrested and officials said one protester had been killed after they were shot by an officer near a military checkpoint in the city of Quetta.
In Karachi, a police vehicle was set on fire and in Lahore, supporters broke into the house of the military corps commander, smashing windows and setting furniture on fire, while shouting: "We warned you not to touch Imran Khan."
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