Scott McTominay put United in front early and a Ben Mee own goal doubled their lead before Cristiano Ronaldo finished impudently to put Ralf Rangnick's men 3-0 up.
Veteran winger Aaron Lennon punctured the party atmosphere at Old Trafford towards the end of the first half, giving Sean Dyche's depleted team hope, but United largely bossed a flat second period.
The Red Devils are now in sixth spot, four points behind fourth-placed Arsenal with a game in hand after interim manager Rangnick shuffled his pack following a disappointing draw at Newcastle.
The German said he still had work to do with his defence but told Amazon Prime “physically and energetically it was a good performance".
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