Trenbolone: The Holy Grail of Steroids?
Muscular Development|October 2021
Powerful Muscle Builder or Monstrosity?
By William Llewellyn

Trenbolone is arguably one of the most potent anabolic steroids in ready use by bodybuilders today. Fueled by a previous and long history of limited availability and high prices, however, a great deal of myth has developed around this steroid. To some, it is the holy grail of steroids – extremely powerful, fast-acting, and anabolic. To others, trenbolone is a monstrosity, too side-effect-prone to consider using for any length of time. This conflict often obscures our understanding of its underlying biological properties.

While I don’t expect we will settle this here and now, a research review paper was published on trenbolone in the medical journal Steroids 1 that is far more thorough than any to come before it. While citing more than 250 individual medical studies, mainly on animals (trenbolone has not been heavily studied in humans), the authors do an excellent job of bringing readers up to date on the current scientific knowledge concerning this controversial steroid. The following is a review of the key points.

No DHT-Type Metabolite

The paper reiterates that trenbolone is not metabolized by the 5-alpha reductase enzyme, which is particularly concentrated in the liver, hair follicles, skin, and prostate. This is the same enzyme responsible for converting testosterone to the more potent steroid dihydrotestosterone (DHT), implicated in some of its adverse effect potential.

The main metabolites of trenbolone (epitrenbolone and trendione) are less active than trenbolone itself, demonstrating that this steroid is not potentiated in the body. Although we normally think of trenbolone as strongly androgenic, the researchers do remind us that it may actually offer a more favorable ratio of anabolic-to-androgenic activity than testosterone. This could mean less chance of prostate growth when used under therapeutic conditions, a common worry with testosterone administration in aging men.

Trenbolone and Estrogen

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