MYOSTATIN AND THE BIG T
Muscular Development|November 2021
Myostatin keeps you from getting huuuuge and stress hormones like cortisol (a glucocorticoid) make it worse. So stop stressin’, OK?
Jose Antonio, Ph.D., FNSCA, FISSN, CSCS

Myostatin is a negative regulator of muscle mass and its effects seem to be exacerbated by glucocorticoids.1-3 What that means in English is that myostatin keeps you from getting huuuuge and stress hormones like cortisol (a glucocorticoid) make it worse. So stop stressin’, OK?

But how does it respond to resistance or weight training? Dr. Darryn Willoughby, professor of exercise physiology, nutritional biochemistry, and clinical anatomy at the University of Mary Hardin-Baylor in Belton, Texas and perhaps the nation’s leading expert in this area (he knows science and he knows how to get huuuuge) looked at 12 weeks of resistance training on the mRNA (messenger RNA) and protein expression of myostatin, myofibrillar protein (as well as other genes) and muscle strength, size and body composition. He took 22 untrained males and randomly assigned them to either a resistance-training group (three times per week; three sets of six reps at about 90 percent of their one-repetition maximum or 1RM; lower extremity exercises) or a control group. Muscle biopsies and blood samples were obtained before and after six and 12 weeks of resistance training.

What did the good doctor find? After 12 weeks of training, subjects increased total body mass, fat-free mass, strength, thigh volume and mass; however, they also increased myostatin mRNA, myostatin, cortisol and myofibrillar protein after six and 12 weeks of training. (And that’s not even the half of it). If you’re confused, join the club.

Dr. Willoughby concluded this: “Resistance training and/or increased glucocorticoid receptor expression appears to upregulate myostatin mRNA expression. Furthermore, it is possible that any plausible decreases in skeletal muscle function from the observed increase in serum myostatin were attenuated by increased serum FLRG levels and the concomitant downregulation of the activin IIb receptor. It is therefore concluded that the increased myostatin in response to cortisol and/or resistance training appears to have no effects on training-induced increases in muscle strength and mass.”1

Here’s My Translation

Continue reading your story on the app

Continue reading your story in the magazine

MORE STORIES FROM MUSCULAR DEVELOPMENTView All

Classic Shawn

10 questions with Shawn Ray

7 mins read
Muscular Development
January 2022

Are You Testosterone Deficient?

On a cloudy day, time moves less clearly than it does on a sunny day. Harken back to the summer days of youth, before the responsibilities of a job or family required one to pay attention to the passage of time. It wasn’t until the streetlights went on that one realized the sun had set and night had covered the neighborhood in a cloak of darkness. The activity on the streets settle as children are called in, even the dogs and squirrels sought shelter as they prepare for their nocturnal slumber.

9 mins read
Muscular Development
January 2022

Glycemic Index and Fat Loss

For many years we were told the keys to losing weight and staying healthy are to exercise and eat a low-fat/high-carbohydrate diet. The public evidently heeded this advice as epidemiological studies have shown that dietary practices of Americans have shifted accordingly. Yet, despite this shift, the incidence of obesity and diabetes in America has reached epidemic proportions, particularly in children and adolescents. This phenomenon has been explained as a result of an increasingly sedentary lifestyle and consumption of nutrient-dense food.

6 mins read
Muscular Development
January 2022

12 Steps to Peak Your Physique in 2022!

Why do we make such a big deal out of a new year? These are after all abstract constructs that we humans came up with to delineate our lives into blocks of time: seconds, minutes, hours, days, weeks, months and years. It’s what a new year represents that’s so important. It’s a chance at a fresh start, a chance to make changes for the better. As bodybuilders, time is always of the essence. It takes time to build muscle and to lose fat, and that’s assuming all methods and conditions are optimal. If they aren’t, you’re usually wasting time when you could be improving. I don’t want you to waste 2022, which is why I’ve come up with 12 steps you can start taking today so that the physique you have at the end of 2022 is superior to the one you started it with. Read on!

10+ mins read
Muscular Development
January 2022

Top 10 Proven Ways To Cut Body Fat

Every year, for every bodybuilder, it’s a quest to shed fat to achieve a state referred to as “shredded,” “peeled” or “cut.” Offseason photos of professional bodybuilders show that many binge and dine their way to obesity, yet within a matter of months, even weeks, they are once again posing in peak condition.

10 mins read
Muscular Development
December 2021

Fully Armed With The Big Rock

No, The Rock (Dwayne Johnson) didn't add the word Big to his name. Like in Star Wars lore, there is another. Another Rock, a bigger Rock. France's Morgan Aste, at 6-foot-3 and 315 pounds on stage actually should be renamed the Biggest Rock, right?

7 mins read
Muscular Development
December 2021

Diuretics and Muscle Definition

The Power and Danger of Lasix

10 mins read
Muscular Development
December 2021

Per BERNAL

Legendary Physique Photographer

8 mins read
Muscular Development
January 2022

HYPERTROPHY-SPECIFIC TRAINING

Proven Concepts Combined to Build Muscle Better

5 mins read
Muscular Development
January 2022

THE KAI FILES

BODYBUILDING CHANGED MY LIFE.

4 mins read
Muscular Development
January 2022