MEDICAL ADVANCES
Central Florida Health News|February 2021
Watson Clinic Launches Clinical Trial of Drug Treatment for Heart Failure
TERESA SCHIFFER

There could be some good news on the horizon for patients who experience acute heart failure. The Watson Clinic Center for Research is beginning a new clinical trial study on a drug to treat this potentially life-threatening medical event. The trial is named DAPA ACT HF-TIMI 68. Board-certified interventional cardiologists Kevin Browne, Jr., MD, and Zia Rab, MD, are the doctors leading this clinical trial of the drug dapagliflozin.

Dapagliflozin is currently approved by the FDA primarily for use in patients who have type 2 diabetes. The sodium-glucose cotransporter-2 (SGLT2) inhibitor helps to improve blood sugar control by removing excess sugar from the body. This is done by helping the kidneys reabsorb glucose from the blood. For patients who are affected by type 2 diabetes as well as either cardiovascular disease or risk factors for cardiovascular disease, dapagliflozin can also reduce the risk of hospitalization due to heart failure. Research has shown that this drug can additionally reduce the risk of worsening heart failure or cardiovascular death in patients showing signs of chronic heart failure, regardless of whether they suffer from diabetes.

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