The Ultimate Immunity Biohack
Better Nutrition|May 2020
Improving your body’s leptin function is a little-known—and powerful—way to enhance your immune function
By Kat James

In a very short time, the average person —and not just here in America—has learned a lot about self-protection to stay well. Social distancing, washing hands, and even self-isolation when we’re sick all play key roles in preventing the spread of novel diseases. And because you read this magazine, I’m guessing you’re pretty well-versed in the supplements and herbs that can bolster your immunity, such as vitamins C and D, zinc, and medicinal mushrooms.

But are you also optimizing your immunity with your food choices? If you carry extra pounds, are diabetic, or deal with cravings, energy swings, or insomnia—in spite of all that you do to stay healthy—you may need to address another issue that dramatically impacts immunity: leptin resistance.

Leptin is a hormone produced by fat cells. It’s also found in smaller amounts in the brain (hypothalamus, pituitary), stomach and intestines, skeletal muscle, breast tissue, cartilage and bone cells, placenta, and immune cells.

Why Leptin Is so Important

Leptin is the “master hormone” that regulates immune function, activating our neutrophils and natural killer (NK) cells, according to research. Poor leptin function, or “leptin resistance,” can hamper proper immune response, contributing to both inadequate and overactive (autoimmune) immune function. Even more amazing, all of this is mostly regulated by the metabolic effects of the foods you eat.

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