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Krupa has appeared on magazine covers including Envy, FHM, Personal, Inside Sport, Stuff, Steppin' Out, Teeze, Shape and Maxim, in which she was named the Sexiest Swimsuit Model in the World. Maxim named her #55 in its 2011 Hot 100 ranking of the world's hottest women. She was voted German Maxim's Model of the Year 2004–2005. Krupa has also appeared twice on the cover of Playboy. Krupa has also been a lingerie model for Frederick's of Hollywood. She was a Miss Howard TV model for the month of December 2007.

Krupa was featured on the television show Superstars in June 2009. She and her partner Terrell Owens were eliminated on the first episode. However, because of another team's injury and disqualification, she and her partner were asked to step in and continue competing. Having taken ballet lessons as a child, Krupa, along with one-time champion Derek Hough, competed in Season 9 of Dancing with the Stars. They were eliminated on 17 November 2009.

In 2004, she starred as Jane Goody in the action film Max Havoc: Curse of the Dragon. Its director Albert Pyun said that he did not want Krupa in the film and she was cast only because she was the client of a friend of producer John Laing. Some critics commented positively on her appearance in the film, although still finding her "stiff."

Since autumn 2010, Krupa has hosted and served as the head judge on the Polish version of Top Model. In 2012, Krupa was announced as one of the new cast members on The Real Housewives of Miami, which premiered on 13 September. Her sister, Marta, also appears on the show.

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