Seven people were taken to hospital for treatment after the accident happened at around 2am yesterday.
North Macedonia's chief prosecutor, Lubomir Jovevski, who visited the scene of the accident, said 12 children were confirmed among the dead.
The cause of the crash was not immediately confirmed, but it appeared that the bus - one of four travelling together - hit a highway barrier, crashed and caught fire.
Photos taken shortly after the crash showed the bus engulfed in flames with plumes of thick black smoke rising from the scene.
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