While moisture in pharmaceutical packaging can have negative or even dangerous effects on its content, unpleasant odours are especially repellent to patients. Both can be systematically prevented using suitable adsorbents – provided the right aspects are taken into account.
Many pharmaceutical products such as tablets and capsules, but also test strips or inhalers are sensitive to moisture. The effects of moisture are manifold and often pose a high risk not only to the drug but also to patients. In the case of tablets, powders and effervescent tablets, the properties and texture may change, whereas gel capsules might dissolve due to moisture. Blood or urine test strips may produce false or misleading results if the test chemical is influenced by too much humidity.
In the worst case, the efficacy of drugs is reduced, or the analytical results are falsified, which can lead to an incorrect medication and impede successful therapy. In addition, many pharmaceuticals, especially analgesics such as acetylsalicylic acid, release specific molecules into the ambient air inside the packaging that can develop very unpleasant odours.
Only real data provides reliable results
The amount of humidity that penetrates into the packaging is decisive for the stability of a moisture-sensitive drug. Around 65% of humidity ingress can be attributed to the packaging. Weak spots can be the packaging wall, the sealing surfaces between containers and closures, as well as the sealing seams of blister packs. Hence the choice of the primary packaging depends mainly on maintaining the optimum climate inside the packaging in order to ensure the required shelf life.
This story is from the July 2018 edition of Pharma Bio World.
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This story is from the July 2018 edition of Pharma Bio World.
Start your 7-day Magzter GOLD free trial to access thousands of curated premium stories, and 8,500+ magazines and newspapers.
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