Scientific India
Vitamin D Supplementation As Preventive Strategy For Tuberculosis Image Credit: Scientific India
Vitamin D Supplementation As Preventive Strategy For Tuberculosis Image Credit: Scientific India

Vitamin D Supplementation As Preventive Strategy For Tuberculosis

Tuberculosis (TB) is a serious worldwide health concern.

About thirty percent of the world population is infected with Mycobacterium tuberculosis which is the causative agent of TB. Immunomodulation through dietary supplementation has been widely used as a mechanism to enhance the immune system. Vitamin D mediates activation of the innate immune system in macrophages which prepare the primary line of defense against infection. After micro-organism detection, toll like receptors (TLR) on the phagocyte membrane is activated to induce transcriptional upregulation of the vitamin D receptor (VDR) and accountable for the VDRdependent regulation responsible for the upregulation of cathelicidin expression. Several studies demonstrate the impact of calcidiol levels, VDR polymorphisms and vitamin D supplementation on the acquisition of TB and the outcomes of TB infections. Increased risk of TB was reported among the people with lower vitamin D levels. Vitamin D supplementation seems to have a positive consequence on TB outcomes. Human monocytes have receptors for 1, 25 dihydroxy vitamin D that activates antimycobacterial responses in human monocytes and macrophages by enhancing phagocytosis and granuloma formation. Calcitriol induces anti mycobacterial activity in vitro. This metabolite modulates the host response to Mycobacterial infection by induction of reactive nitrogen and oxygen i


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