For vaccines, thermostability is the key to successful global immunization programs as it can have a significant impact on the continuous cold-chain maintenance logistics, as well as on the vaccine potency. The stability of such a vaccine comes under increasing regulatory scrutiny, due to its potential effect on immunogenicity and the difficulties involved in its characterisation.
In order to comprehensively characterise stability and aggregation of vaccines, this article demonstrates the advantages of Multispectral Advanced Nanoparticle Tracking Analyser (ViewSizer™ 3000) from HORIBA Scientific. The ViewSizer 3000 can be used to understand the insights of particle sizing and viral titer  in the range of 10 nm to 15 μm. The combined capabilities of particle visualization, particle size and concentration measurements enable unmatched characterization and real-time monitoring of common kinetic processes such as dissolution of active pharmaceutical ingredients, self-assembly of polymers, crystallization of food and pharmaceutical products, aggregation of proteins, and particle agglomeration.
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