Solid Dosage: Technologies To Tablet Effervescent Products
Pharma Bio World|February 2019
Solid Dosage: Technologies To Tablet Effervescent Products

Tableting effervescent products is a complex process.

Yet, with the right technology, these tablets can be produced just as rapidly and safely as regular oral solid dosage forms. Romaco Kilian has the perfect solution for compressing effervescent formulations with maximum efficiency. Children are particularly fond of effervescent products because, quite simply, they’re fizzy. As such, the beverage and confectionery sectors offer an enormous variety of products, as does the pharmaceutical industry, such as pain relievers, cough syrups or medications for the gastrointestinal tract. A broad array of nutraceuticals is also available, often in several different flavours. The administration of water-soluble drugs is particularly recommended for children, the elderly or patients with swallowing difficulties or a sensitive stomach.

Tablets with complex demands

Effervescent tablets offer many consumer benefits; but, manufacturing and processing these hygroscopic products inevitably presents a number of complicated hurdles to overcome. By their very nature, effervescent tablets react extremely vigorously with air, light and moisture. In addition, many of the active pharmaceutical ingredients (APIs) and vitamins processed in effervescent formulations are readily affected by heat. Furthermore, effervescent tablets tend to be friable and susceptible to breakage. All these factors must be considered when tableting effervescent powders. The Romaco Kilian KTP 590X tablet press is tailor made for these kinds of applications.

Gentle compression

Effervescent tablets are naturally prone to unwanted air pockets and capping, which is why the tableting process takes place in three steps. The Kilian KTP 590X single-sided rotary press is consequently equipped with three separate compression stations. The first compression roller simply tamps the powder. Next, the tablets are precompressed; in the third step, they are converted into finished products in the main compression unit. The use of Kilian 28/41 tooling simultaneously extends the dwell time, meaning that harder tablets can be made because there is more overall time for deaeration. This stops the tablets from bursting during subsequent processing steps.

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February 2019