Equine Cushing's Disease

HQ magazine|March/April 2020

Equine Cushing's Disease
A pituitary problem

The disease most commonly occurs in middle-aged and geriatric horses and ponies, with an average age of approximately 20 years at the time of diagnosis. Ponies are more commonly affected than horses, but there is no difference in the prevalence in mares or geldings. Current estimates suggest that between 20 and 33% of all horses and ponies develop PPID by the age of 20 (kentucky Equine Research Center). This makes PPID the most common endocrine condition of horses worldwide. Without treatment, symptoms get worse over time, and many horses are euthanized because of laminitis.


In dogs and humans, Cushing’s disease is caused by a hormone-secreting tumour in the front part (pars distalis) of the pituitary gland, which is found at the base of the brain. In horses, on the other hand, the disease involves the intermediate part of the pituitary gland (pars intermedia). This part of the gland is comprised of different hormone-secreting cells than the front part of the pituitary gland. Therefore, equine Cushing’s disease looks quite different to Cushing’s disease in dogs and humans. It is for this reason that many vets now prefer to refer to the condition in horses as PPID.


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March/April 2020