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Nature and Nurture Anne Wojcicki raised her genetic-testing company, 23andMe, from a wonky wunderkind through a troubled adolescence. Now her $2.5 billion biotech machine is ready to take the next step, combining big data and big pharma. Decoding the DNA of Silicon Valley’s most personal creation. By Biz Carson and Kathleen Chaykowski. Serena’s Net Gains The most successful woman athlete ever is now translating her game and name into startup investing and entrepreneurial ventures. And she’s figured out a formula that will make it hard for her to lose. By Kurt Badenhausen. The Richest Self-Made Women From Rihanna to Stitch Fix’s Katrina Lake, more women are creating new businesses and amassing fortunes than ever before. As a result, Forbes expanded our ranking of the nation’s wealthiest women entrepreneurs to 80 ceiling crashers. Edited by Luisa Kroll and Kerry A. Dolan.