THE MIDDLEMAN OF MIDDLE AMERICA David Zalik never graduated from high school, much less college. But the numbers whiz could do the math: Making money from both sides of a home-renovation loan, without the risk of defaults, can make you a billionaire. EYES ON THE ROAD How Velodyne’s vision sensors are ushering in the self-driving-car revolution. THE PRICE OF INSPIRATION Vertex Pharmaceuticals’ new $200,000-a-year cystic fibrosis drug could help 90% of patients breathe. It’s an amazing—and profitable—innovation. But will that windfall spur the 28-yearold startup to do it again?